role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other
CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as
upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which
encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to
synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to
the same pathogenetic process that leads to the malignancy.-">

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Mouse Monoclonal Antibody to BCL-10
Western blot analysis using BCL10 mouse mAb against NIH/3T3 (1), Hela (2), MCF-7 (3) and Jurkat (4) cell lysate.
Mouse Monoclonal Antibody to BCL-10
Confocal Immunofluorescence analysis of Hela cells using BCL10 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
Mouse Monoclonal Antibody to BCL-10
Flow cytometric analysis of Hela cells using BCL10 mouse mAb (green) and negative control (purple).
Mouse Monoclonal Antibody to BCL-10
Immunohistochemical analysis of paraffin-embedded human breast carcinoma (A) and liver carcinoma (B), showing cytoplasmic localization using BCL10 mouse mAb with DAB staining.
Mouse Monoclonal Antibody to BCL-10
Mouse Monoclonal Antibody to BCL-10
Mouse Monoclonal Antibody to BCL-10
Mouse Monoclonal Antibody to BCL-10

Mouse Monoclonal Antibody to BCL-10

  • 貨號：

    20003

  • 別名：

    CLAP; Me10; CIPER; c-E10; CARMEN

  • 產品上架時間：

    2024-03-23

  • 應用：

    WB,IHC,IF,FCM

  • 反應種屬：

    Human,Mouse

  • 抗體類型：

    Primary antibody

  • Swissprot：

    O95999

  • 規格：

  • 數量：

    -
    +

  • 說明書：

    目錄價￥2180

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Mouse Monoclonal Antibody to BCL-10

Description

Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important
role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other
CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as
upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which
encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to
synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to
the same pathogenetic process that leads to the malignancy.

References
1. Willis, T.G., et al. (1999) Cell. 96, 35-45.
2. Lucas, P.C., et al. (2001) J. Biol.Chem. 276, 19012-19019.
3. Wang, L., et al. (2001) J. Biol.Chem. 276, 21405-21409

Specification
Aliases CLAP; Me10; CIPER; c-E10; CARMEN
Entrez GeneID 8915
Swissprot O95999
clone 4F8
WB Predicted band size 26kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse
Immunogen Purified recombinant fragment of human BCL-10 expressed in E. Coli.
Formulation Purifed antibody in PBS with 0.05% sodium azide.

Application
WB 1/500 - 1/2000
IHC 1/200 - 1/1000
IF/ICC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000